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Dasatinib and quercetin improved motor and neuromuscular outcomes in TDP-43Q331K ALS mice.

Senolytic treatment with dasatinib and quercetin improved motor behavior and neuromuscular function in TDP-43Q331K ALS mice. The treatment reduced axonal damage, measured by plasma neurofilament light chain, and preserved motor cortex excitability and layer V neuron counts. Cortical microglia showed lower TDP-43 burden and fewer senescence markers. These results point to cellular senescence as an early, modifiable feature of ALS pathology.

Meta

Date: 09-2026

Evidence type: Journal Article

Compounds: Quercetin

Effects: senolytic activity

PMID 42759848

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